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ProteomicsA patient-based Drosophila model for mitochondrial S-Adenosylhomocysteine transport deficiency
The SLC25A26 gene encodes a mitochondrial inner membrane carrier that transports S-adenosylmethionine (SAM) into the mitochondrial matrix in exchange for S-adenosylhomocysteine (SAH). SAM is the predominant methyl-group donor for most cellular methylation processes, of which SAH is produced as a by-...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-01-19 | PXD026900 | Pride
Sam Samc Methylation Sah Mitochondria Drosophila Slc25a26 
ProteomicsDirect proteome labelling in fruit flies with SILAF reveals differential phosphorylation of mitochondrial proteins upon loss of OXPHOS subunits
Drosophila melanogaster has been a workhorse of genetics and cell biology for more than a century. However, proteomic-based methods have been limited due to the complexity and dynamic range of the fly proteome and the lack of efficient labelling methods. Here, we advanced a chemically defined food s...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-10 | PXD009990 | Pride
Holidic Fly Silaf Bsf Fruit fly Oxphos Lrpprc Silac Drosophila Methods development Drosophila melanogaster 
ProteomicsSQSTM1/p62-directed metabolic reprogramming is essential for normal neurodifferentiation
Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the ageing population, but their aetiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases, with known genetic cause, provides an opportunity to unde...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD006647 | Pride
Mitophagy Neurodifferentiation Hypoxia Mitochondria Oxidative stress Neuroepithelial-like stem cells P62 Sqstm1 Neuronal development 
ProteomicsDrosophila NFS1.R77 is required for differential protein complex composition
S-adenosylmethionine (SAM) is the principle biological methyl group donor for a diverse range of substrates. It is synthesised in the cytosolic methionine cycle and shuttled throughout the cell. The mitochondrial SAM (mitoSAM) pool depends on import through the inner-membrane SAMC and supports the m...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-22 | PXD019551 | Pride
Nfs1 Drosophila Iron sulphur clusters 
ProteomicsMethyl-SILAF mapping of the Drosophila mitochondrial protein methylome
S-adenosylmethionine (SAM) is the principal biological methyl group donor for a diverse range of substrates. It is synthesised in the cytosolic methionine cycle and shuttled throughout the cell. The mitochondrial SAM (mitoSAM) pool depends on import through the inner-membrane S-adenosylmethionine ca...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-21 | PXD019654 | Pride
Ptm Mitochondria Methylation Drosophila 
ProteomicsModelling mitochondrial SAM depletion in fruit flies and mice
S-adenosylmethionine (SAM) is the principle biological methyl group donor for a diverse range of substrates. It is synthesised in the cytosolic methionine cycle and shuttled throughout the cell. The mitochondrial SAM (mitoSAM) pool depends on import through the inner-membrane SAMC and supports the m...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2021-02-22 | PXD019550 | Pride
Metabolism Methylation Mitochondria Sam 
ProteomicsAngel2 phosphatase activity is required for non-canonical mitochondrial RNA processing
Canonical RNA processing in mammalian mitochondria is defined by tRNAs acting as recognition sites for nucleases to release flanking transcripts. The relevant factors, their structures, and mechanism are well described, but not all mitochondrial transcripts are punctuated by tRNAs, and their mode of...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2022-09-01 | PXD033394 | Pride
Angel2 Mitochondria Processing Mouse Rna Drosophila 
ProteomicsThe mitochondrial methylome is evolutionary conserved and regulated by cytosolic SAM
S-adenosylmethionine (SAM) is the principle biological methyl group donor for a diverse range of substrates. It is synthesised in the cytosolic methionine cycle and shuttled throughout the cell. The mitochondrial SAM (mitoSAM) pool depends on import through the inner-membrane SAMC and supports the m...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2021-02-22 | PXD019494 | Pride
Mitochondria Prm Human Mouse Methylation Drosophila 
ProteomicsProteomics in fibroblasts from mitochondrial disease patients
Evaluation of proteomic profiles in fibroblasts obtained from patients with genetically confirmed mitochondrial disease.
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD047313 | Pride
Mitochondrial disease Fibroblasts Lfq-dda Vus 
ProteomicsThe mitochondrial methylation potential gates early and late ribosome assembly
S-adenosylmethionine (SAM) is the principal methyl group donor of the cell, required to modify various molecules, including DNA, RNA and proteins. Inside mitochondria, SAM is associated with several steps of mitochondrial gene expression. However, the exact role and significance of these modificatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-19 | PXD055907 | Pride
Sam Rna processing Elac2 Methylation Rnasep Mitochondrial ribosome Mitochondrial translation S-adenosylmethionine Samc Rnasez Adomet Slc25a26 
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