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ProteomicsProteomic analysis of the extracellular and intracellular role of IL-33 in primary human endothelial cells
IL-33 is a nuclear cytokine from the IL-1 family that plays important roles in health and disease.Under healthy conditions, IL-33 is constitutively expressed to high levels in the nucleus of producing cells in various human and mouse tissues. The extracellular function of IL-33 cytokine has been wel...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD004117 | Pride
Cytokine Inflammation Endothelial cells Human Fractionation Shotgun Il-33 Huvec 
ProteomicsProteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A
We analyzed the total proteome of group 2 innate lymphoid cells (ILC2s) after different stimulation with interleukin-33 (IL-33), a cytokine playing a critical role in human asthma, and TL1A, a TNF-family cytokine also known to activate ILC2s. Upon combined stimulation with IL-33 plus TL1A, we show t...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-05 | PXD041987 | Pride
Tl1a Cytokine Il33 Group 2 innate lymphoid cells Ilc2 Whole cell lysate Allergic inflammation Type 2 response Proteome Alarmin 
ProteomicsComparative proteomic analysis of mouse CD4+Foxp3+ regulatory T cells and CD4+Foxp3- conventional T cells
In this study, we compared the proteomes of mouse CD4+Foxp3+ regulatory T cells (Treg) and CD4+Foxp3- conventional T cells (Tconv) in order to build a data set of proteins differentially regulated in these two cell populations. The data set contains mass spectrometry results from the analysis of 7 b...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-10 | PXD004436 | Pride
Mouse primary t cell Expression proteomics Label-free Foxp3 Regulatory t cells 
ProteomicsMass spectrometry analysis of the Themis1 interactome in murine thymocytes
Themis1, a recently described T-lineage specific protein, is essential for thymic positive and negative selection. Although Themis1 has been clearly identified as a component of the T cell antigen receptor (TCR) signalosome, its precise role in TCR signaling remains unclear. Here, we used quantitati...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-06 | PXD004072 | Pride
Thymocytes Ap-ms Tcr signalling Themis1 Interactome 
ProteomicsComparative analysis of the proteome of CD4+ T cells overexpressing or not the FOXK1 transcription factor
Foxk1 is a transcription factor described to be involved in metabolism control. To investigate its role in T cell activation, and characterize the molecular pathways modulated by FOXK1, we analyzed by quantitative mass spectrometry the proteomes of CD4+ T cells transduced with a vector containing th...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-31 | PXD080837 | Pride
Dia-pasef Cd4 t-cells Mouse Proteome 
ProteomicsComparative analysis of the proteome of CD4+ T lymphocyte from WT or FOXK1 KO mice
Foxk1 is a transcription factor described to be involved in metabolism control. To investigate its role in T cell activation, and characterize the molecular pathways modulated by Foxk1, we determined by quantitative mass spectrometry analysis, the proteomes of control and Foxk1-/- CD4+ T cells activ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-31 | PXD064444 | Pride
Total proteome Foxk1 Mouse cd4+ t cells 
ProteomicsComparative analysis of the proteome of CD8+ T lymphocyte from WT or FOXK1 KO mice
Foxk1 is a transcription factor described to be involved in metabolism control. To investigate its role in T cell activation, and characterize the molecular pathways modulated by Foxk1, we determined by quantitative mass spectrometry analysis, the proteomes of control and Foxk1-/- CD8+ T cells eithe...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-31 | PXD080759 | Pride
Murine Cd8 t-cells Proteome 
ProteomicsProteomic analysis of platelets isolated from mice deficient for IL-33 or treated with recombinant IL-33
Platelets, traditionally recognized for their involvement in hemostasis and wound healing, also play a central role in immune regulation and inflammation. Their function and production adapt in response to inflammatory cues such as cytokines and danger-associated molecular patterns. Interleukin-33 (...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD068068 | Pride
Interleukin-33 Global proteome Platelets Allergy 
ProteomicsAnalysis of the interactome of the RLTPR/CARMIL2 protein in CD4+ T cells
We analyzed the interactome of the mouse protein RLTPR (CARMIL2) using an affinity purification method based on the introduction of a One-Strep-tag (OST) sequence in the C-terminus of the bait protein by genetic engineering of primary mouse T cells. We used mouse models expressing the tagged version...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD055893 | Pride
Ap-ms Primary t cell Rltpr Interactome Ost tag Carmil2 
Proteomicsyeast-UPS1 standard LC-MS/MS dataset
Proteomic workflows based on nanoLC-MS/MS data-dependent-acquisition analysis have progressed tremendously in recent years due to the technical improvement of mass spectrometers, and now allow to extensively characterize complex protein mixtures. High-resolution and fast sequencing instruments have ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2015-12-01 | PXD001819 | Pride
Yesat Ups1 Label-free quantification Lc-ms/ms 
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