Sort   by:  
 Page size 
ProteomicsImmunopeptidome analysis of 4T1 murine breast cancer cells.
This study aimed to identify Tumor Associated Antigens (TAA)s by Immunoaffinity purification of MHC peptides and LCMS analysis, verifying their immunogenicity and testing their tumor control potential in a highly aggressive preclinical model of triple-negative breast cancer in mice. Among the MHC pe...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD016112 | Pride
Cancer Ligandome Orbitrap fusion Mouse Murine Immunopeptidome Mhc-i 4t1 
ProteomicsHiRIEFII proteomics and proteogenomics of A431 cells and five histologically normal tissues
High Resolution Isoelectric Focusing (HiRIEF) LC-MS was used to analyze samples from the human A431 cell line and also samples of histologically normal tissues. The high analytical depth afforded by HiRIEF permitted proteogenomics on these two sample sets (A431 cells and normal tissues). The A431 d...
ORGANISM(S): Homo sapiens (Human) 
2018-01-19 | PXD006291 | Pride
A431 Testis Kidney Liver Tonsil Human Placenta 
ProteomicsIimmunopeptidomics pipeline for generation of personalized oncolytic cancer vaccines.
We used a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumour cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. We used MHC-I immunoaf...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-06 | PXD026463 | Pride
Mouse Oncolytic virus Colon cancer Personalized cancer vaccines Ct26 Ligandome Cancer vaccines Murine Immunopeptidome 
ProteomicsProteomic and phosphoproteomics profiling of breast cancer cells with altered expression level of the protein phosphatase TRAP
Tartrate-resistant acid phosphatase (TRAP/ACP5) is a metalloenzyme of the group of acid phosphatases. High levels of TRAP protein have been associated with the development of cancer metastasis and with clinically relevant parameters of cancer progression and cancer aggressiveness. In order to invest...
ORGANISM(S): Homo sapiens (Human) 
2017-09-04 | PXD006430 | Pride
Breast cancer Tgfbeta Cd44 Acp5 Mda-mb-231 Trap Migration Silac Cell adhesion Proliferation Tmt Tgf Extracellular matrix 
ProteomicsLCMS quantification of internal crosslink in WT and G68L mutant R2lox proteins from Geobacillus kaustophilus.
A heterobimetallic Mn/Fe cofactor is found in the R2 subunit of class Ic ribonucleotide reductases (R2c) and R2-like ligand-binding oxidases (R2lox). Although the protein-derived metal ligands are the same in both groups of proteins, the connectivity of the two metal ions and the chemistry each cofa...
ORGANISM(S): Geobacillus kaustophilus 
2019-10-31 | PXD015549 | Pride
Ferritin  metalloprotein  ribonucleotide reductase  r2-like ligand-binding oxidase  r2lox  crosslink 
ProteomicsHiRIEF LC-MS allows for in depth quantitative analysis of the phosphoproteome.
In this project we aimed at improving phosphoproteomics analysis by taking advantage of high resolution isoelectric focusing (HiRIEF) fractionation. We developed a workflow that employs titanium dioxide phospho-enrichment, followed by isobaric labeling with Tandem Mass Tags (TMT) and HiRIEF on a bro...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD005410 | Pride
Multiplex Cells Isoelectric point Tmt Phospho-peptides Phospho-sites Fractionation Quantification Networkin Cancer Phosphoproteomics Tyrosine Ipg Proteomics Hirief 10-plex Lc-ms Quantitative Mitosis Mitotic arrest Hela Kinase association Multiply phosphorylated Phosphorylation Pervanadate 
ProteomicsImmunopeptidomics of Acute Myeloid Leukemia (AML) Blast cells after Therapy-Induced Senescence (TIS) with Cytarabine.
Resistance or relapse upon chemotherapy are major determinants of treatment failure in acute myeloid leukemia (AML). Therapy-induced senescence (TIS) is a potential outcome of chemotherapy, but its immunological consequences in AML remain unclear. We show that ex-vivo chemotherapy induces senescence...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD068731 | Pride
Immunopeptidomics Therapy-induced senescence Tis Hla Ligandome Mhc Cytarabine Ligandomics Immunopeptidome Timstof scp Acute myeloid leukemia Aml 
Proteomics,MultiomicsHiRIEFII proteomics and proteogenomics of A431 cells and five histologically normal tissues
High Resolution Isoelectric Focusing (HiRIEF) LC-MS was used to analyze samples from the human A431 cell line and also samples of histologically normal tissues. The high analytical depth afforded by HiRIEF permitted proteogenomics on these two sample sets (A431 cells and normal tissues). The A431 d...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-04 | MSV000083000 | MassIVE
Sort   by:  
 Page size