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ProteomicsZNF184 Negatively Regulates HR Repair and Predicts Poor Prognosis in Acute Lymphoblastic Leukemia
Zinc finger proteins (ZNFs) are increasingly recognized as regulators of oncogenic transcriptional networks and DNA damage responses. Through integrative analysis of bulk and single-cell RNA sequencing data, we identified a conserved set of seven ZNF genes, including ZNF184, that are upregulated in ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD066624 | Pride
Negative regulator Lc-ms/ms Acute lymphoblastic leukemia Zinc finger proteins Homologous recombination repair Trim28 
ProteomicsNSMF promotes the replication stress-induced DNA damage response for genome maintenance
Proper activation of DNA repair pathways in response to DNA replication stress is critical for maintaining genomic integrity. Due to the complex nature of the replication fork (RF), problems at the RF require multiple proteins, which remain unidentified, for resolution. In this study, we identified ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021942 | Pride
Atr Cdc5l Rpa2 Replication fork Lc-ms/ms 
ProteomicsNew insights into the role of peptide from Allomyrina dichotoma larvae in ameliorating lipid metabolism in vitro and in vivo
The aim of this study was to identify anti-obesity peptide from Allomyrina dichotoma (A. dichotoma) and investigate the biochemical signaling pathway. For that, A. dichotoma larvae was hydrolyzed enzymatically, and further purified by using tangential flow filtration and consecutive chromatographic ...
ORGANISM(S): Allomyrina 
2021-09-09 | PXD019661 | Pride
Lc-msms Allomyrina dichotoma larva  insulin resistance  lipid metabolism Peptides 
ProteomicsMetabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the “Warburg effect”, which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD006036 | Pride
Acetylation Sirt2 Differentiation Human pluripotent stem cells 
ProteomicsEwing sarcoma protein-mediated regulation of poly(ADP-ribose) polymerase 1 dissociation
Poly(ADP-ribose) polymerase 1 (PARP1) critically facilitates DNA damage response (DDR) that suppresses genomic instability. However, the physiological function of PARP1 in regulating genomic integrity is unclear. We investigated the Ewing’s sarcoma breakpoint region 1 (EWS) and found that it regulat...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-03 | PXD016145 | Pride
Ews Dna damage response (ddr) Parylation Parp-1 Par 
ProteomicsIsolation and identification of extracellular matrix proteins from oil-based CASPERized mouse brains for matrisomal analysis
The extracellular matrix (ECM) components present within all tissues and organs help to maintain the cytoskeletal architecture and tissue morphology. Although the ECM plays a role in cellular events and signaling pathways, it has not been well studied due its insolubility and complexity. Brain tissu...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD028272 | Pride
Ecm Brain O-casper Profiling Decellularization 
ProteomicsPeptidylarginine deiminase 2 (PADI2) is a key regulator for osteoblast differentiation and bone formation through the maintenance of citrullination-mediated RUNX2 stability
Peptidylarginine deiminase (PADI) 2 catalyzes the posttranslational conversion of peptidyl-arginine to peptidyl-citrulline, a process called citrullination. However, the exact function of PADI2 in bone development and bone homeostasis remains unknown. In this study, we found that Padi2 deficiency le...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040179 | Pride
Citrullination Ptm Padi2 Lc-msms Runx2 
ProteomicsProteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms
Ultraviolet (UV)-induced DNA lesions threaten genomic stability and are associated with skin carcinogenesis. These lesions are primarily repaired by the nucleotide excision repair (NER) pathway. However, alternative repair mechanisms and regulators are emerging as critical contributors to managing U...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD061212 | Pride
Uv Uv Dek Numa1 Dna damage 
ProteomicsATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair
Mono-ubiquitinated PCNA (mono-Ub-PCNA) is generated when replication forks stall and facilitates the DNA lesion bypass process. After resolving a replication stall, Ub-PCNA needs to be de-ubiquitinated to resume high-fidelity DNA synthesis. ATAD5 cooperates with UAF1-USP1 to de-ubiquitinate mono-Ub-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050108 | Pride
Baz1b De-ubiquitination Dna repair Usp1 Smarca5 Atad5 Baz1b Uaf1 Pcna 
Proteomicspyruvate dehydrogenase kinase 4 regulate mitochondrial dynamics
Mitochondrial dynamics provides cells with the flexibility required to adapt and respond to mitochondrial toxins, yet the mechanisms underpinning the regulation of mitochondrial dynamics machinery by these stimuli is poorly understood. Here we show that pyruvate dehydrogenase kinase 4 (PDK4) is requ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD028379 | Pride
Pyruvate dehydrogenase kinase 4 Silac Mitochondrial dynamics Drp1 
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